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DC Field | Value | Language |
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dc.contributor.advisor | Graham, Andrea L | - |
dc.contributor.author | Perkins, Sarah | - |
dc.date.accessioned | 2021-08-19T14:14:38Z | - |
dc.date.available | 2021-08-19T14:14:38Z | - |
dc.date.created | 2021-04-19 | - |
dc.date.issued | 2021-08-19 | - |
dc.identifier.uri | http://arks.princeton.edu/ark:/88435/dsp014m90dz62g | - |
dc.description.abstract | Mounting evidence that the type 2 cytokine IL-13 is upregulated by endurance training to jointly mediate helminth resistance and endurance capacity suggests an energetic tug-of-war between endurance exercise and helminth infection playing out in evolutionary time. First, this study examined the link between IL-13 and exercise in an ecologically viable rewilded mouse model, testing the prediction that more active mice are more likely to launch an IL-13 response against antigenic stimuli in MLN assays. Considering two cohorts of rewilded mice (N = 97), activity was a unique predictor of binomial production of IL-13 (p < 0.05) among the cytokines examined including IL-10, IFNγ, and IL-17. Furthermore, this effect was mediated directly by host pathways rather than the gut microbiome, with no clear association between activity and microbiome profile or diversity. The exercise-IL-13 link was then examined across a larger group of 34 laurasiatherian mammals to test an expected endurance-helminth species richness evolutionary correlation and look for signals of intensified selection on IL-13 pathway genes in species with high endurance capacities. No evolutionary correlation was found in OLS or PGLS models, suggesting co-evolutionary complexity across the phylogeny. However, selection was intensified on Il13ra1 (p < 0.01) and relaxed on Gata3 (p < 0.001) among high-endurance test lineages, implicating the IL-13 pathway in endurance capacity evolution and implying potential constitutive GATA-3 production or Th2-regulatory evolution in high-endurance states. These findings highlight endurance as a crucial factor in the helminth-host co-evolutionary race, mediated by the IL-13 pathway at physiological and evolutionary scales. | en_US |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en_US |
dc.title | The race against helminths: physiological and evolutionary impacts of endurance exercise on the IL-13 immune response | en_US |
dc.type | Princeton University Senior Theses | |
pu.date.classyear | 2021 | en_US |
pu.department | Ecology and Evolutionary Biology | en_US |
pu.pdf.coverpage | SeniorThesisCoverPage | |
pu.contributor.authorid | 920006013 | |
pu.mudd.walkin | No | en_US |
Appears in Collections: | Ecology and Evolutionary Biology, 1992-2023 |
Files in This Item:
File | Description | Size | Format | |
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PERKINS-SARAH-THESIS.pdf | 1.64 MB | Adobe PDF | Request a copy |
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