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Title: Effects of Post-reproductive Caloric Restriction on Lifespan in C. Elegans
Authors: O'Donnell, James
Advisors: Murphy, Coleen
Department: Molecular Biology
Class Year: 2014
Abstract: Caloric restriction (CR) is arguably the most consistent method of increasing healthy life span across a wide variety of organisms. Despite its growing popularity in the media and fitness circles, little is known about the effects of late-onset CR in post reproductive animals. This research directly addresses the question of whether late-onset CR has the same longevity effects as lifelong CR. I compare lifelong, post reproductive-onset, or early-life-only CR in the nematode C. elegans, a popular model organism for aging research. In my initial trial, I found that CR produces a rapid and reversible decrease in mortality rate and corresponding increase in lifespan, though more replications are needed before definitive conclusions can be made. To the best of my knowledge, this research investigates delayed-onset solid-plate CR in C. elegans for the first time. Findings from this model may shed some light on the potential effects of adult- onset caloric restriction in humans.
Extent: 45 pages
Type of Material: Princeton University Senior Theses
Language: en_US
Appears in Collections:Molecular Biology, 1954-2020

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