MAGNETIC FLOW CYTOMETERS (MFCS) ACHIEVED BY A 2D OSCILLATOR ARRAY FOR RARE CELL TRACKING AND MULTI-SITE DETECTION

Abstract

In the paper, a 2D oscillator array-based magnetic sensor CMOS IC is presented for flow cytometry. The CMOS IC packaged with a 2mm in width microfluidic channel eliminates the need for hydro-focusing and enhanced the throughput for detection by allowing uninhibited flow over the 2D chip surface. The chip exploits multi-site detection capability facilitating/allowing simultaneously high throughput cell tracing, flow rate monitoring, real-time cell tracking and ultra-low false detection rates. We demonstrate these functionalities with a 7×7 oscillator array in 65nm CMOS technology.