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Title: Genome Architecture And Phenotypic Evolution
Authors: Tandon, Dhriti
Advisors: vonHoldt, Bridgett M
Contributors: Ecology and Evolutionary Biology Department
Keywords: Evolution
Subjects: Biology
Evolution & development
Issue Date: 2023
Publisher: Princeton, NJ : Princeton University
Abstract: While investigating phenotypic change, evolutionary studies in non-model systems have mostlylooked at the first order genomic structure, which encompasses sequence level polymorphisms. In my dissertation, I reveal that the genetic architecture of phenotypic change can be embedded in several layers of genomic information, hereafter referred to as primary (sequence-level), secondary (epigenetic modifications of DNA base pairs) and tertiary (chromatin architecture) levels. In my first chapter, I report primary sequence level polymorphisms associated with breed behavioral profiles in dogs and track the demographic history of genomic regions associated with behavioral traits under selection. In my second chapter, I report epigenetic modifications that could allow a non-adapted low-land deer mouse population to dynamically modulate genes promoting tolerance to hypoxia, a feature of high attitudinal habits. In my third chapter, I bridge the gap between a high-effect non-coding variant implicated in canine hyper-sociability and its functional impacts on gene regulation, via investigating and incorporating information from 3D genome architecture at the tertiary level. I hope that my work provides a novel approach to look at evolutionarily imperative genetic changes as more than just a collection of base pairs, but a culmination of intermediate molecular processes along several levels of the genomic information.
Type of Material: Academic dissertations (Ph.D.)
Language: en
Appears in Collections:Ecology and Evolutionary Biology

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