Skip navigation
Please use this identifier to cite or link to this item: http://arks.princeton.edu/ark:/88435/dsp019g54xh85r
Full metadata record
DC FieldValueLanguage
dc.contributor.advisorKang, Yibin-
dc.contributor.authorKang, Jooeun-
dc.date.accessioned2014-07-28T13:20:06Z-
dc.date.available2014-07-28T13:20:06Z-
dc.date.created2014-04-24-
dc.date.issued2014-07-28-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/dsp019g54xh85r-
dc.description.abstractTubulointerstitial nephritis antigen like 1 (Tinagl1) is a poorly-characterized secreted matricellular protein studied mostly in the context of development. Here, we demonstrate the role of Tinagl1 in suppressing breast cancer metastasis, in part through its dose-dependent influence on cancer cell migration and inhibition of the canonical Wnt signaling pathway activation. Serum starvation resulted in a decrease of Tinagl1 expression, suggesting that Tinagl1 is also involved in cell stress recognition pathways. Importantly, Tinagl1 expression is negatively correlated with metastatic potential of human breast and mammary tumor cells, and increased presence of Tinagl1 in vivo, either through ectopic expression of Tinagl1 in tumor cells or treatment with recombinant Tinagl1, correlate with a decrease in pulmonary metastasis. Our observation that Tinagl1 affects cellular signaling rather than morphology suggests that Tinagl1 acts as a mediator protein for signaling pathways such as Wnt with diverse downstream effects that results in metastasis suppression. We therefore propose Tinagl1 as a potential therapeutic agent as well as a metastasis biomarker.en_US
dc.format.extent90 pagesen_US
dc.language.isoen_USen_US
dc.titleThe Characterization of Tubulointerstitial Nephritis Antigen-like 1 as a Secreted Metastasis Suppressor in Breast Canceren_US
dc.typePrinceton University Senior Theses-
pu.date.classyear2014en_US
pu.departmentMolecular Biologyen_US
pu.pdf.coverpageSeniorThesisCoverPage-
Appears in Collections:Molecular Biology, 1954-2023

Files in This Item:
File SizeFormat 
Kang_Jooeun.pdf2.51 MBAdobe PDF    Request a copy


Items in Dataspace are protected by copyright, with all rights reserved, unless otherwise indicated.