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Title: The Role of the Striatum in Working Memory
Authors: Akhlaghpour, Hessameddin
Advisors: Witten, Ilana B
Contributors: Neuroscience Department
Keywords: Basal Ganglia
Sequential Activity
Working Memory
Subjects: Neurosciences
Issue Date: 2017
Publisher: Princeton, NJ : Princeton University
Abstract: Several lines of evidence suggest that the striatum has an important role in spatial working memory. The neural dynamics in the striatum have been described in tasks with short delay periods (1-4s), but remain largely uncharacterized for tasks with longer delay periods. We collected and analyzed single unit recordings from the dorsomedial striatum of rats performing a spatial working memory task with delays up to 10s. We found that neurons were activated sequentially, with the sequences spanning the entire delay period. Surprisingly, this sequential activity was dissociated from stimulus encoding activity, which was present in the same neurons, but preferentially appeared towards the onset of the delay period. These observations contrast with descriptions of sequential dynamics during similar tasks in other brains areas. Ongoing experiments using temporally precise perturbations at different phases of working memory are aimed to clarify the contribution of the striatum in spatial working memory.
Alternate format: The Mudd Manuscript Library retains one bound copy of each dissertation. Search for these copies in the library's main catalog:
Type of Material: Academic dissertations (Ph.D.)
Language: en
Appears in Collections:Neuroscience

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