Skip navigation
Please use this identifier to cite or link to this item:
Title: Nanoparticle Encapsulation for the Solubility Enhancement of Oral Therapeutics
Authors: Caggiano, Nicholas
Advisors: PriestleyPrud'homme, RodneyRobert DK
Contributors: Chemical and Biological Engineering Department
Keywords: emulsions
Flash NanoPrecipitation
Subjects: Chemical engineering
Pharmaceutical sciences
Issue Date: 2023
Publisher: Princeton, NJ : Princeton University
Abstract: Nanoparticle encapsulation is an attractive technique for the solubility enhancement of poorly soluble oral therapeutics since the increased specific surface area of the nanoparticles promotes rapid dissolution kinetics while avoiding the need for chemical modification of the drug molecule. Additionally, for nanoparticles produced by rapid quenching or precipitation, the resulting amorphous drug core can offer thermodynamically increased solubility relative to the crystalline form. We employ Flash NanoPrecipitation (FNP), a scalable self-assembly process which uses turbulent mixing and rapid precipitation, to form polymer-stabilized core-shell nanoparticles with high core loading (~50% or higher). However, in our application of FNP to hydrophobic small molecules and peptides we show that the physical and chemical properties of therapeutics can present obstacles to nanoparticle formulation. We describe nanoparticle formulations of cannabidiol, a hydrophobic small molecule oil, using FNP. However, the low density of cannabidiol required development of a new method to characterize in vitro dissolution from cannabidiol-loaded nanoparticles. In the case of delamanid, a hydrophobic but highly crystalline small molecule, surface stabilizer attachment during self-assembly was inhibited by suspected incompatibility caused by the fluorinated and nitro-substituted drug molecule. Therefore, emulsification was used as an alternative route to prepare delamanid-loaded nanoparticles for global health applications. In both the case of cannabidiol and delamanid, the nanoparticle formulations greatly enhanced in vitro dissolution kinetics. Comparative studies formulating cannabidiol and delamanid as amorphous solid dispersions highlighted the advantages of nanoparticles for solubility enhancement and physical stability. We also applied FNP to a family of oral peptides displaying systematic structure and property variations to highlight differences in nanoparticle composition required for successful formulation of hydrophobic and hydrophilic peptides. Lastly, we present a sequential, two-mixer FNP process which temporally separates core precipitation and stabilizer attachment to limit stabilizer entrainment and enable higher core loadings of up to 90%.
Type of Material: Academic dissertations (Ph.D.)
Language: en
Appears in Collections:Chemical and Biological Engineering

Files in This Item:
File Description SizeFormat 
Caggiano_princeton_0181D_14645.pdf6.85 MBAdobe PDFView/Download

Items in Dataspace are protected by copyright, with all rights reserved, unless otherwise indicated.