Skip navigation
Please use this identifier to cite or link to this item:
Title: Stimulating the Brain and Spinal Cord: A Short-Circuit or the Future of Targeted Therapy?
Authors: Jia, Tim
Advisors: Gould, Elizabeth
Department: Neuroscience
Certificate Program: Global Health and Health Policy Program
Class Year: 2022
Abstract: Movement disorders such as Parkinson’s disease, essential tremor, and dystonia are incurable and can be resistant to pharmacological treatment. These and other neuropsychiatric disorders can significantly reduce quality of life and cause an economic burden. Deep-brain stimulation (DBS) has been shown to alleviate symptoms as an advanced therapeutic for some disease indications. Similarly, spinal cord stimulation (SCS) has been used for cases of chronic pain. However, the mechanisms of either are unclear. This narrative literature review aims to understand the mechanism behind DBS and SCS in order to evaluate potential synergies and future developments. Neurostimulation from DBS and SCS is suggested to regulate dysfunctional imbalances by modulating local and network activity and influencing glial cells. Developments and technological advances point towards targeted therapeutic interventions implementing optimized and adaptive closed-loop stimulation based on patient-specific neuroimaging and biomarkers. Future research can look into effects of multi-target stimulation, simultaneous use of DBS and SCS, and varying stimulation parameters.
Type of Material: Princeton University Senior Theses
Language: en
Appears in Collections:Neuroscience, 2017-2022
Global Health and Health Policy Program, 2017-2022

Files in This Item:
File Description SizeFormat 
JIA-TIM-THESIS.pdf742.19 kBAdobe PDF    Request a copy

Items in Dataspace are protected by copyright, with all rights reserved, unless otherwise indicated.