Skip navigation
Please use this identifier to cite or link to this item: http://arks.princeton.edu/ark:/88435/dsp01zw12z549v
 Title: ULTRASONIC TRANSDUCERS FOR PERIPHERAL NERVE REGENERATION STUDIES Authors: Alberti, Silvana F. Advisors: McAlpine, Michael C. Contributors: Littman, Michael G. Department: Mechanical and Aerospace Engineering Class Year: 2014 Abstract: This thesis examined the design, fabrication, and characterization of piezoelectric- based ultrasonic platforms for the study of mechanically-stimulated peripheral nerve regeneration. The effect of ultrasound generated by piezoelectric cantilever transducers on cell culture environment was examined using dye and neutrally buoyant beads. Both studies showed mechanical energy generated by the piezoelectric cantilever transducers could be transmitted into the cell culture environment to potentially affect cell behavior. Thin-film transducers based on the piezoelectric polymer polyvinylidine fluoride (PVDF) were also designed given the ability to potentially assemble the material into a nerve guidance channel. Alternatively, a novel composite material of poly(lactic-co-glycolic acid (PLGA) containing peptide nanotubes was also examined for potential thin-film transducers. Impulse response measurements obtained from the thin-film devices showed a clear difference between poled and un- poled films when actuated at 20 Hz. X-ray diffraction measurements suggest that the PVDF exhibited a crystalline structure that could be made polar. Studies with the nanotube composite material indicated the weight fraction of the nanotubes <1 wt% failed to generated measurable piezoelectric response in the bulk material suggest- ing the bulk PLGA film could be made piezoelectric by using a more concentrated nanotube network. Extent: 80 pages URI: http://arks.princeton.edu/ark:/88435/dsp01zw12z549v Type of Material: Princeton University Senior Theses Language: en_US Appears in Collections: Mechanical and Aerospace Engineering, 1924-2016

Files in This Item:
File SizeFormat
Alberti_File_Copy-2.pdf8.95 MBAdobe PDF

Items in Dataspace are protected by copyright, with all rights reserved, unless otherwise indicated.