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Please use this identifier to cite or link to this item: http://arks.princeton.edu/ark:/88435/dsp01qf85nd734
Title: GERM CELL GENOTOXICITY THE LASTING EFFECTS OF PEDIATRIC CANCER THERAPY
Authors: Wetlinski, Catherine
Advisors: Notterman, Daniel A.
Department: Molecular Biology
Class Year: 2016
Abstract: In this thesis, I set out to examine fertility as a late effect of pediatric cancer therapy. I determine why fertility is an inadequate measure of the reproductive fitness of adult cancer survivors and explore the causes of deficits in fertility after pediatric cancer therapy. I focus mainly on the male germ cell line, exploring various sperm genomic damages that occur as a result of chemotherapy and/or radiotherapy in childhood and adolescence. Although sperm chromosome aneuploidy presents as a consequence of pediatric cancer therapy, I worry more with sperm DNA fragmentation, which includes single-strand and double-strand DNA breaks, which are genotoxic and have the ability to be transmitted to offspring. I find, however, that although DNA-impaired spermatozoa may fertilize an egg, it is unlikely for these damages to remain in the embryo or for the embryo to remain.
Extent: 75 pages
URI: http://arks.princeton.edu/ark:/88435/dsp01qf85nd734
Type of Material: Princeton University Senior Theses
Language: en_US
Appears in Collections:Molecular Biology, 1954-2016

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