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Title: Intra- and Intermolecular Anti-Markovnikov Hydroamination of Unactivated Olefins with Alkylamines
Authors: Naguib, Saeed Gamil
Advisors: Knowles, Robert R.
Department: Chemistry
Class Year: 2016
Abstract: While the addition of N-H bonds across an olefin represents a green and direct method for the formation of amine products central to many branches of academic research and industry, catalytic hydroaminations with anti-Markovnikov selectivity remain rare. Based on a classical olefin amination reaction that proceeds through an aminium radical cation, herein we report protocols for both an intra- and intermolecular anti-Markovnikov hydroamination of unactivated olefins with simple alkylamines using an iridium visible-light photocatalyst in conjunction with an H-atom donor. A range of alkyl amines, including β-aminoalcohols, have been prepared under these mild catalytic conditions in good to excellent yields.
Extent: 42 pages
Type of Material: Princeton University Senior Theses
Language: en_US
Appears in Collections:Chemistry, 1926-2017

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